Carbon Monoxide Poisoning

Removal from the Body:

Rationale for the Use of Hyperbaric Oxygen (HBO) Therapy in CO Poisoning:

Principle Mechanism
Enhance COHb elimination from the body Mass action: oxygen competes with CO for hemoglobin binding site
Enhance CO elimination from myoglobin and cytochrome oxidase Mass action: oxygen competes with CO for iron / copper binding sites in tissue
Maintain oxygen delivery to tissue Oxygen: 2.1% by volume per ATA is physically dissolved in plasma
Reduce cerebral edema and intracranial pressure Vasoconstrictive effect of HBO
Decrease leukostasis HBO inhibits B2 integrin function

From: Piantadosi, C.A., 1999. Diagnosis and treatment of carbon monoxide poisoning. In: Respiratory Care Clinics of North America, Hyperbaric Medicine, Part II, 5 (2), pgs. 183-202.

...... last changed 07/02/02

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