Carbon Monoxide Headquarters



Carbon Monoxide Toxicity:



Interactive Effects of other Substances

Substance
Additive
Synergistic
Antagonistic
Comment
Barbiturate . .
+
Via reduction of cell metabolism
Carbon Dioxide .
+
. .
Cyanide .
+
. Increases respiration, leading to faster CO uptake
Ethanol . .
+
Some authors believe it has an "independent" effect
Methylene Chloride .
+?
. CO formation in tissues
Carbon Tetrachloride . .
+
Inhibition of liver oxidases (by CO)
Trichloroethylene .
+
. Direct toxic effect on CNS cells
Nitrous oxide .
+
. Blocks hemoglobin function like CO
Sodium Nitrite
+
. . .
Sulfur Dioxide
+
. . .

From: Jain, K.K. (1990) Carbon Monoxide Poisoning, Warren H. Green, Inc., St. Louis, MO



...... last changed 12/25/99


Interactions with CO Toxicity

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