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Carbon Monoxide Poisoning

The Haldane Effect:

These plots show the effect of carbon monoxide on the oxygen dissociation curve, the so-called Haldane Effect. I = 0% COHb, II = 10% COHb, III = 25% COHb, IV = 50% COHb, V = 75% COHb. As more CO attaches to hemoglobin, the oxygen dissociation curve for that hemoglobin that can still carry oxygen shifts to the left and comes to take on a hyperbolic shape rather than a sigmoidal shape.

See: Maynard, R.L. & Waller, R. (1999) Carbon monoxide. In: Air Pollution and Health, Academic Press, New York, Chpt. 33, pgs. 749-796.

...... last changed 02/20/00

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