Hypothesis diagram illustrating possible mechanisms of neuronal injury after CO hypoxia. Dashed lines indicate untested possibilities. EAA = excitatory amino acids, CAT = catecholamines, Cyt a,a3 = cytochrome c oxidase, MAO = monoamine oxidase, L-arg = L-arginine, cNOS = constitutive nitric oxide synthase, ROS = reactive oxygen species. From: Piantadosi, C.A., Toxicity of carbon monoxide: Hemoglobin vs. histotoxic mechanisms. Chpt. 8, Pgs. 163-186. In: Penney, D.G., Carbon Monoxide, 1996.
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