Cardiac Muscle, Dr. D. Penney
Mechanisms for Changing Pacemaker Cell Automaticity:
- Hyperpolarize/hypopolarize overdrive suppression
- Alteration of slope (rate of rise) of pre-potential (diastolic potential)
- Alteration of threshold; e.g. epinephrine increases gCa++ (hypopolarizes), acetylcholine increases gK+ (hyperpolarizes)
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