Page 3, O2 Uptake, Exercise & Cor. Circ., Dr. D. Penney

Ischemia:

An increased A-VO2 difference at rest usually indicates ischemia.

Ischemia is relieved by increasing blood flow, or decreasing O2 consumption, or both.

Increased A-V lactate indicates inadequate flow. The heart usually uses lactate (i.e. the A-V lactate diff. is negative), but in ischemia or hypoxia it produces lactate, so the A-V lactate diff. becomes positive.

Other indicators of ischemia are:

  • release of enzyme (LDH, CPK) into the coronary venous blood
  • acute alteration in height of the ST segment
  • change in the T wave


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