Developmental Pathophysiology, Develop. Physiol., Dr. D. Penney
Table 4.19 - Characteristics in pulmonary stenosis.
- Obstruction to RV outflow increases afterload of RV; to eject normal flow the RV must increase systolic pressure (P = F x R); resultant increase in wall stress leads to cardiomegaly. Chamber volume remains normal, if compensated, since flow is not increased.
- May be subvalvular, valvular, or supravalvular.
- Beyond the stenosis, pulmonary resistance is normal, so large pressure gradient is present across the obstruction.
- No shunt occurs unless there is a defect in septae; thus no cyanosis.
- No symptoms occur unless RV cannot compensate to provide normal flow.
- RV enlargement is seen by ECG, RV heave felt.
- Loud, harsh systolic ejection murmur is heard; if valve is compliant an early systolic click occurs.
| valve area = | stroke flow -------------------------------------------- 0.5 x mean pressure gradient |
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