Developmental Pathophysiology, Develop. Physiol., Dr. D. Penney
Table 4.16 - Characteristics of Ventricular Septal Defects (the most common heart defect).
Small/restrictive VSD:
- Tiny crevice size to 50 - 60% of aortic diameter; orifice of defect limits maximal flow such that RV pressure doesn't reach systemic.
- Blood shunted across defect proportional to defect size; flow from LV to RV occurs throughout systole giving a pansystolic murmur.
- O2 step-up seen in RV relative to RA; increase proportional to extent of shunt flow.
- Pulmonary blood flow increases; increase in lung vascularity is seen on X-ray.
- X-ray, ECG & echocardiography determine degree of enlargement.

Altered pressures and saturation -
| Normal | small VSD |
| RA | 2 | 5 |
| RV | 20 | 25 |
| PA | 20/5 (12) | 25/10 (17) |
| PA | 70% | 85% |
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