Developmental Pathophysiology, Develop. Physiol., Dr. D. Penney
Table 4.03. Major historical examples of environmental agents that have seriously affected human development.
- Alcohol - thousands of years; fetal alcohol abuse syndrome.
- Cigarettes - low birth wt., increased risk of miscarriage, mental retardation?
- Lead - first noted in 1897 that only 61 children were alive out of 210 births in a group of women working with lead.
- Rubella - effects first described in 1941 (cataracts, patent ductus arteriosus, stillbirth, deafness).
- Thalidomide - 1959/62; phocomelia (delay in development of the limb buds in 10,000 infants.
- Love Canal, PBB in Michigan, etc., etc.
- Carbon Monoxide - from combustion devices
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