Later Development, Develop. Physiol., Dr. D. Penney

Table 3.07 - DPG-Hemoglobin Interactions.

• 2,3-DPG stabilizes deoxyconformation of HbA, thus increases P₅₀; no effect on Hb_F (striped Hb_A P₅₀ = 12.6, Hb_F P₅₀ = 13.2)

• Increased DPG, increases P₅₀

• Increased pH, increases 2,3-DPG concentration & vice versa

• Decreased HbO₂ saturation, increases pH, which increases DPG concentration

• Decreased pH, right shifts the ODC and increases P₅₀ (Bohr Effect)

• CO₂ binding to Hb is decreased by O₂ (Christianson-Douglas-Haldane Effect)

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